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Percocet Side Effects


Percocet side effects include side effects related to the Oxycodone component as well as those related to the acetaminophen component.  Often, side effects are most pronounced during overdose so these are discussed below.

Percocet side effects related to the Oxycodone component affect the respiratory and cardiovascular systems as well as alertness and various other symptoms.  The Percocet side effects of the respiratory system include decreasing respiratory rate, shallow breathing, and sometimes breath-holding followed by periods of deep sighing breathing.  This leads to decreased oxygen content and peripheral cyanosis.  Cardiovascular symptoms related to percocet side effects include severe hypotension and slow heart rate.  In overdose, cessation of breathing, circulatory collapse, and cardiac arrest may occur.  Some of the more benign Percocet side effects include clammy skin, decreased alertness potentially leading to coma, and pupil constriction.

Percocet Side Effects
Percocet Side Effects


Percocet side effects related to the acetaminophen component primarily affect the liver and kidney.  Dose dependant hepatic necrosis (liver cell death) can occur and if severe enough can be fatal.  Percocet side effects affecting the kidney can cause renal tubular necrosis.  This severely impairs the functionality of the kidney.  Other Percocet side effects related to acetaminophen include coma resulting from low blood sugar and low platelet count in the blood (thrombocytopenia).

Early Percocet side effects of an overdose causing potential liver damage include nausea, vomiting, sweating and a general feeling of being unwell. 


Percocet side effects are apparent at any dose and it is the dosage in the particular person that determines the severity of the Percocet side effects.